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On-going Project (42)

Independent projects (8)

1. Minsuk Kwak, Nam Hyeong Kim, Yong Ho Kim*, Young-wook Jun*, “Cadherin-mediated phase separation of lipid raft modulates membrane proteolysis of Notch and APP”. 

2. Nam Hyeong Kim, Yong Ho Kim*, Young-wook Jun*, “Elucidating the association of gamma-secretase with lipid rafts through MD simulation”. 

3. Nam Hyeong Kim+, Woon Ryoung Kim+, Yong Ho Kim*, Young-wook, Jun*, “Localization of lipid raft on Contactin-Caspr junction of paranode in neuron”. 

4. Nam Hyeong Kim, Juran Moon, Geun Young Jin, Deok Hyang Sa, Hyejin Kwon, Young Hyun No, Jiyoung Nam, Eun Sung Kang, Thach Thanh Trung, Kratochvil Huong, Bagchi, Sayan, William F. DeGrado*, Yong Ho Kim*, Yung Sam Kim*, “Correlation between Conformational Changes in a Transmembrane Protein and its Pore-Water Dynamics”. 

5. Beomjun Choi+, Nam Hyeong Kim+, Yong Ho Kim*, Gilho Eom*, “Elucidation the structural role of monomer and dimer state for oligomerization of islet amyloid polypeptide”. 

6. Suhyeon Kim, Deok Hyang Sa, Nam Hyeong Kim, Kyeong Hyun Kim, Seongpil An*, Yong Ho Kim*, “Recombinant adhesive protein-based surface immobilization of AMP for chronic wound treatment”. 

7. Young Hyun No+, Seon Hwa Park+, David Youn, Nam Hyeong Kim, Kook-Han Kim, Yong-Tae Kim, Eun Ji Park, Yang Gyun Kim, One-Sun Lee, Wan Soo Yun*, Young Dok Kim*, Yong Ho Kim*, “Understanding the effect of alpha-helix structural stability on hydrophobic interactions of peptides with hydrophobic solid surface”. 

8. Hayeon Bae, Do Hyun Bae, Suhyeon Kim, Yong Ho Kim*, “Efficiency improvement of anti-aging and lipolysis peptide for skin care using functional iontophoresis mask”. (제목미정)


BBB sub-group projects (8)

1. Young Hyun Noh, Jiyoung Nam, Hojae Choi, Nam Hyeong Kim, Hayeon Bae, Soo-Yeon Lee, Yong Ho Kim*, “Design of BBB Transporting Peptide through Transferrin Receptor”

2. Hayeon Bae, Jiyoung Nam, Yong Ho Kim*, “Development of a Novel Cell Penetrating Peptide (CPP) for Drug Delivery System”

3. Soo-Yeon Lee, Jiyoung Nam, Yong Ho Kim*, “Nonconvalent Conjugation of siRNA with BBB Transporting Peptide for Brain Cancer Therapy”

4. Zinah Hilal Khaleel, Do Hyun Bae, Eui Chul Lee, Yong Ho Kim*, “Comparative Target Delivery Studies of Paclitaxel-transpep Conjugates via Cleavable and Non-cleavable Linkers” 

5. Young Hyun Noh, Yong Ho Kim*, "Design of Blood-Brain Barrier-Crossing Antibodies Targeting CNS Diseases with Transferrin-Mimic Peptides"

6. Young Hyun Noh, Yong Ho Kim*, "Blood-Brain Barrier-Crossing GLP-1 Agonist for the Treatment of Type 2 Diabetes with Transferrin-Mimic Peptides"

7. Young Hyun Noh, Eui Chul Lee, Yong Ho Kim*, "Cancer Therapeutics Allosteric K-RAS G12C Covalent Inhibitors Targeting Transferrin Receptor"

8. Hojae Choi, Nicholas Polizzi, Ketaki Belsare, Nam Hyeong Kim, William DeGrado*, Yong Ho Kim*, De novo Design of BBB Penetrating Peptide through Transferrin Receptor”


Cas9 sub-group projects (12)

1. Khanh Van Do, Thach Thanh Trung, Seong Chan Park, Nam Hyeong Kim, Young Hyun Noh, Shahzad Zafar, Eun Sung Kang, Zinah Hilal Khaleel, Yang Gyun Kim, Yong Ho Kim*, "CRISPR/Cas9 Engineering for broadening PAM recognition"

2. Thach Thanh Trung, Eun Sung Kang, Khanh Van Do, Young Hyun No, Nam Hyeong Kim, Bok Soo Lee, Kyungtae Kim, Zinah Hilal Khaleel, Jiyoung Nam, Euna Lee, Han-Joo Kim, Jaecheol Lee*, Yong Ho Kim*, "Direct intracellular delivery of engineered SaCas9 for efficient gene suppression"

3. Nam Hyeong Kim, Thach Thanh Trung, Eun Sung Kang, Seong Chan Park, Van Khanh Do, Yong Ho Kim*, “De Novo Design of Cas9 for Rebuilding the PAM interacting domain to diversify PAM recognition" 

4. Thach Thanh Trung, Khanh Van Do, Yong Ho Kim*, "Structure determination of EnCas9, Cas12, Cas14"

5. Muhammad Shahzad Zafar, Thach Thanh Trung, Khanh Van Do, Yong Ho Kim*, "CRISPR sensor using Cas9, Cas12, Cas14"

6. Seong Chan Park, Eun Sung Kang, Thach Thanh Trung, Khanh Van Do, Yong Ho Kim*, " Transpep-mediated Cas9 delivery into Brain CNS"

7. Thach Thanh Trung, Khanh Van Do, Yong Ho Kim*, "New Cas9 Enzyme Design"

8. Thach Thanh Trung, Muhammad Shahzad Zafar, Eun Sung Kang, Khanh Van Do, Seong Chan Park, Yong Ho Kim*, "Activity control genome editing with an engineered Cas9 using protease"

9. Thach Thanh Trung, Nam Hyeong Kim, Khanh Van Do, Yong Ho Kim*, "Biochemical and functional studies of new CRISPR/Cas9"

10. Eun Sung Kang, Seong Chan Park, Thach Thanh Trung, Do Hyun Bae, Yong Ho Kim*, “GBM gene editing through CRISPR/Cas9 Ribonucleoprotein delivery based on BBB penetrating lipopeptide nanosome engineering”

11. Seong Chan Park, Thach Thanh Trung, Eun Sung Kang, Ho Jae Choi, Yong Ho Kim*, "Development of BBB penetrating functionalized fusion CRISPR/Cas9"

12. Khanh Van Do, Thach Thanh Trung, Seong Chan Park, Nam Hyeong Kim, Young Hyun Noh, Eun Sung Kang, Yang Gyun Kim, Yong Ho Kim*, “Development of PAM-Independent Cas9 system using structural analysis


1DNW sub-group projects (2)

1. Nam Hyeong Kim+, Sudong Chae+, Deok Hyang Sa+, Suhyeon Kim, Seongbae Oh, Eun Sung Kang, Jae Yong Choi*, Yong Ho Kim*, “Solubilizing the single chain atomic crystal through designed peptide”

2. Sang Ah Yi, Nam Hyeong Kim, Sudong Chae, Deok Hyang Sa, Ki Hong Nam, Su Hyeon Kim, Ji Young Nam, Jae Young Choi*, Jae Cheol Lee*, Yong Ho Kim*, “Regulation of stem cell differentiation mimicking extracellular matrix through peptide-1DNW complex”


RNAi sub-group projects (2)

1. Kyeong Hyun Kim, Maria Razzaq, Nam Hyeong Kim, Jiyoung Nam, Bok Soo Lee*, Yong Ho Kim*, “A new GFP knockdown system to promote endosomal escape through M2 proton channel

2. Jiyoung Nam, Bok-Soo Lee, Yong Ho Kim*, “Cell penetrating peptide mediated siRNA delivery using peptide nucleic acid as a universal linker”


Antibody sub-group projects (3)

1. Young Hyun Noh, Muhammad Shahzad Zafar, Hyun Sub Ji, Yong Ho Kim*, "Highly sensitive bio-sensor for real-time detection of narcotics using artificial antibody that is fusion of coiled-coil protein and scFv"

2. Young Hyun Noh, Yong Ho Kim*, "Development of a nanobio-active sensor for highly-reliable ultra-fast detection of single biomolecules using artificial antibody"

3. Young Hyun Noh, Yong Ho Kim*, "Development of neurotransmitter receptor protein motivated artificial antibody to detect narcotics"


Complex sub-group projects (5)

1. Eun Sung Kang, Dawon Park, Yong Ho Kim*, “A Modular Approach for Supramolecular Protein Assembly by Chemical-induced peptide building blocks”

2. Zinah Hilal Khaleel, Do Hyun Bae, Young Hyun No, Yong Ho Kim*, “Photoswitchable Calmodulin Calcium Binding Motif Mimic for Calcium Imaging”

3. Do Hyun Bae, Hayeon Bae, Deok Hyang Sa, Yong Ho Kim*, "Development transdermal drug delivery to increase ability of skin penetrating and hair-growth"

4. Do Hyun Bae, Hayeon Bae, Deok Hyang Sa, Yong Ho Kim*, "Discovery of highly potent tyrosinase inhibition peptide with anti-melanogenesis ability"

5. Do Hyun Bae, Hayeon Bae, Deok Hyang Sa, Yong Ho Kim*, "Effective inhibition of skin cancer, anti-melanogenesis by peptide-based hybrid drug"


Biocoating sub-group projects (2)

1. Suhyeon Kim, Kyeong Hyun Kim, Zinah Hilal Khaleel, Young Hyun Noh, Yong Ho Kim*, “Maleimide-thiol conjugation chemistry-based controllable surface coating of recombinant vitronectin protein on polystyrene plate for stem cell growth control”

2. Suhyeon Kim, Kyeong Hyun Kim, Young Hyun Noh, Yong Ho Kim*, “Design of novel mussel-originated adhesive protein”

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