Bok Soo Lee
bslee114@skku.edu


1994.2.25. 
Chungnam National Univ., Korea Biology (Cellular Immunology), Ph.D.
1989.2.25. 
Chungnam National Univ., Korea Biology (Cellular Immunology), M.S.
1984.2.25. 
Chungnam National Univ., Korea Biology, B. S.


Postdoctoral Training

1998.5.1- 2004.10.06 
 Research fellow, Div. of Tumor Virology, NEPRC, Harvard Medical School, USA 

1996.4.1- 1998.4.30
 Postdoctoral fellow, Cellular Immunol. Lab., Ochsner Clinic Foundation, USA

1994.4.1-1996.03.27
 Postdoctoral fellow, Lab. of Immunology, Korea Research Institute of Bioscience &Biotechnology (KRIBB)


Professional Positions

2010.9.1-present 
Research Prof., SungkyunKwan University School of Medicine/ Researcher, Samsung Biomedical Research Institute, Samsung Medical Center.

2006.9.1-2010.8.31 
 Research Associate Prof., SungkyunKwan University School of Medicine/ Researcher, Samsung Biomedical Research Institute, Samsung Medical Center.

2004.10.1-2006.8.31. 
 Research Professor, Department of Microbiology & Immunology, Wonkwang University School of Medicine

2005.9.1-2006.2.22
 Lecturer, Wonkwang University School of Medicine

2005.9.1-2006.2.25 
 Lecturer, Department of Biology, Chungnam National University

2005.3.1-2005.8.25 
 Lecturer, Department of Biotechnology, Joosung College

1992.3.2-1995.2.25 
 Lecturer, Department of Biology, Chungnam National University

1991.3.1-1994.2.28
 Research and Teaching assistant, Dept. of Microbiol. & Immunol. Wonkwang Medical School



Professional Activities 

2006 - present Member of American Heart Association
2005 - present 세포생물학회 회원
2003 - present Member of the AAI (American Association of Immunologists)
2003 - present Member of the FASEB (Federation of American Societies for Exp. Biology)
2003 - present Member of the IUIS (International Union of Immunological Societies)
2003 - present Member of American Society for Microbiology




Publication

Lee BS, Lee BC, Park JE, Choi HK, Choi SJ, Soh KS. Primo vascular system in human umbilical cord and placenta. J Acupunct Meridian Stud. 2014 Dec; 7(6):291-7. doi: 10.1016/j.jams.2014.09.002. Epub 2014 Oct 20. PMID: 25499562

Chan K1, Patel RS, Newcombe P, Nelson CP, Qasim A, Epstein SE, Burnett S, Vaccarino VL, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, El Mokhtari NE, Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Whittaker JC, Tang WH, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H, Richards AM, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ, Ye S. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol. 2013 Mar 5;61(9):957-970. doi: 10.1016/j.jacc.2012.10.051. PMID: 23352782

Ji-Young Lee,* Bok-Soo Lee,* Dong-Jik Shin,* Kyung Woo Park*, Young-Ah Shin, Kwang Joong Kim, Lyong Heo, Ji Young Lee, Yun Kyoung Kim, Young Jin Kim, Chang Bum Hong, Sang-Hak Lee, Dankyu Yoon, Hyo Jung Ku, Il-Young Oh, Bong-Jo Kim, Juyoung Lee, Seon-Joo Park, Jimin Kim, Hye-kyung Kawk, Jong-Eun Lee, Hye-kyung Park, Jae-Eun Lee, Hye-young Nam, Hyun-young Park, Chol Shin, Mitsuhiro Yokota, Hiroyuki Asano, Masahiro Nakatochi, Tatsuaki Matsubara, Hidetoshi Kitajima, Ken Yamamoto, Hyung-Lae Kim, Bok-Ghee Han, Myeong Chan Cho, Yangsoo Jang, Hyo-Soo Kim, Jeong Euy Park and Jong-Young Lee. A genome-wide association study of a coronary artery disease risk variant. J Hum Genet. 2013 Mar. 58:120-126. doi: 10.1038/jhg.2012.124. PMID: 23364394 (*co-first)

Lee BS, Kim JY, Choi JY, Lee JY, Han SH, Kim KY, Park JE. Reconstituted high-density lipoprotein attenuates atherogenesis partly by regulating HSP27 in hyperlipidemic apoE(-/-) mice. Int J Cardiol. 2013 Jul; 167(2): 585-587. doi: 10.1016/j.ijcard.2012.09.226. Epub 2012 Oct 30. PMID: 23117011

Lee BS, Choi JY, Kim JY, Han SH, Park JE. Simvastatin and losartan differentially and synergistically inhibit atherosclerosis in apolipoprotein e(-/-) mice. Korean Circ J. 2012 Aug; 42(8):543-50. PMID: 22977450

Yangsoo Jang, Dawn Waterworth, Jong-Eun Lee, Kijoung Song, Sujin Kim, Hyo-Soo Kim, Kyung Woo Park, Hyun-Jai Cho, Il-Young Oh, Jeong Euy Park, Bok-Soo Lee, Hyo Jeong Ku, Dong-Jik Shin, Jong Ho Lee, Sun Ha Jee, Bok-Ghee Han, Hye-Yoon Jang, Eun-Young Cho, Patrick Vallance, John Whittaker, Lon Cardon, and Vincent Mooser. Carriage of the V279F null allele within the gene encoding Lp-PLA2 is protective from coronary artery disease in South Korean males. PLoS One. 2011 Apr 5;6(4):e18208. (ISSN-e 1932-6203, IF 4.26?, San Francisco, CA: Public Library of Science, USA, PMID: 21490708)

Jo Woon Yi Lee*, Bok-Soo Lee*, Ji Yeun Lee, Hyo Jung Ku, So-Ra Jeon, Joo Yun Kim, Ji Min Ban, Sang Hyun Sung, Heung Mook Shin and Jeong Euy Park. The herbal extract HMC05 inhibits neointima formation in balloon-injured rat carotid arteries: possible therapeutic implications of HMC05. J Ethnopharmacol. 2011 Jan 7;133(1):168-76. (ISSN 0378-8741, IF 2.26, Elsevier Sequoia, Ireland, PMID: 20883768)

Young-Myeong Kim, Hyun-Ock Pae, Jeong Euy Park, Yong Chul Lee, Je Moon Woo, Nam-Ho Kim, Yoon Kyung Choi, Bok-Soo Lee, So Ri Kim, Hun-Taeg Chung. Heme oxygenases in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2010 Jul 12. [Epub ahead of print] (ISSN 1523-0864, IF 8.209, Mary Ann Liebert,Inc., USA. PMID: 20624029)

Jin-Oh Choi, Cheol-Woong Yu, Jong Chun Nah, Jeong Rang Park, Bok-Soo Lee, Yu Jeong Choi, Byung-Ryul Cho, Sang-Chol Lee, SeungWoo Park, Akinori Kimura, Jeong Euy Park. Long-term outcome of 4 Korean families with hypertrophic cardiomyopathy caused by 4 different mutations. Clin Cardiol. 2010 Jul;33(7):430-8. (ISSN:0160-9289, IF 1.211, Hoboken, NJ : John Wiley & Sons, Inc, PMID:20641121)

Se-Hwa Kim, Eun-Soo Lee, Jae Yong Lee, Eun Seong Lee, Bok-Soo Lee, Jeong Euy Park and Dae Won Moon. Multiplex coherent anti-stokes Raman spectroscopy images intact atheromatous lesions and concomitantly identifies distinct chemical profiles of atherosclerotic lipids. Circ Res. 2010 Apr 30;106(8):1332-1341. (ISSN 0009-7330, IF 9.989, Lippincott Williams & Wilkins, USA. PMID: 20299664)

Lee JY, Lee JWY, Choi JY, Kim JY, Lee BS, Shin HM, Park JE. Effect of HMC05, a herbal extract, on collagen systhesis in vascular smooth muscle cells. Korean Hypertension J. 2009. 15(1):25-34.

Choi JY, Lee BS, Lee JY, Kim JY, Sung SH, Shin HM, Park JE. Hesperidin, isolated from an herbal extrct HMC05, inhibits LPS-induced IL-1b expression in THP-1 cells and leukocyte infiltration in atherosclerotic lesions of high fat high cholesterol fed apoE-/- mice. Korean Hypertension J. 2009. 15(1):25-34.

Hinohara K, Ohtani H, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A. Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease. J Hum Genet. 2009 Nov;54(11):642-6. (ISSN 1434-5161, IF 2.205, Springer Verlag, Japan, NLM ID: 9808008)

Kunihiko Hinohara, Toshiaki Nakajima, Taishi Sasaoka, Motoji Sawabe, Bok-Soo Lee, Ji-Min Ban, Jeong-Euy Park, Toru Izumi and Akinori Kimura. Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations. J Hum Genet 2009 Sep; 54(9):554-556 (ISSN 1434-5161, IF 2.205, Springer Verlag, Japan, NLM ID: 9808008)

Kunihiko Hinohara, Toshiaki Nakajima, Michio Yasunami, Shigeru Houda, Taishi Sasaoka, Ken Yamamoto, Bok-Soo Lee, Hiroki Shibata, Yumiko Tanaka-Takahashi, Megumi Takahashi, Takuro Arimura, Akinori Sato, Taeko Naruse, Jimin Ban, Hidetoshi Inoko, Yoshiji Yamada, Motoji Sawabe, Jeong-Euy Park, Toru Izumi and Akinori Kimura Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease Hum Genet 2009 Oct; 126(4):539-547 (ISSN 0340-6717, IF 3.662, Springer Verlag, Germany, NLM ID: 7613873)

Kunihiko Hinohara, Toshaki Nakajima, Taishi Sasaoka, Motoji Sawabe, Bok-Soo Lee, Ji Min Ban, Jeong Euy Park, Toru Izumi, and Akinori Kimura. Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations. J Hum Genet 2009 Mar 13; 54(4):248-251 (ISSN 1434-5161, IF 2.205, Springer Verlag, Japan, NLM ID: 9808008)


Oral presentations

Bok-Soo Lee*, Chien-an Andy Hu, David Valle, and Jae U. Jung. Tyrosine phosphorylation independent interaction of KSHV K1 with cellular pyrolidone -5- carboxylate reductases (P5CR).
( 3rd International workshop on KSHV and related agents.)

Bok-Soo Lee*, Ronald S. Veazey, John S. Mathew, Andrew A. Lackner, and Jae U. Jung. Kaposi’s sarcoma-associated herpesvirus K1 protein induces lymphoproliferative diseases in transgenic mice. ( 3rd International workshop on KSHV and related agents.)

Ji-Hyun Cho, Bok-Soo Lee*, Andy Hu, David Valle, and Jae Jung. Cellular prrroline-5-carboxylate reductase (P5CR) is a common target for gamma-2 herpesvirus transforming proteins. (4th International workshop on KSHV and related agents.)

Invited presentation

Tyrosine phosphorylation independent interaction of KSHV K1 with cellular pyrolidone -5- carboxylate reductases (P5CR). 9th New England BioScience (NEBS) KOREA Society annual meeting, Boston, MA