Kook Han Kim
hani5736@skku.edu

 
2006.09 - 2011.02
 Ph.D., Biotechnology and Genetic Engineering , Korea University, Seoul, Korea
2003.09 - 2005.08
 M.S., Life Sciences and Biotechnology, Korea University, Seoul, Korea
1995.03 - 2002.08
 B.S., Microbiology, Chungnam National University, Daejeon, Korea

Publications 

1. Jiyoung Nam, Yong-Tae Kim, Aeyeon Kang, Kook-Han Kim, Kyo Ree Lee, Wan Soo Yun, and Yong Ho Kim. Lipid reconstitution-enabled formation of gold nanoparticle clusters for mimetic cellular membrane. Journal of Nanomaterials. vol. 2016, Article ID 2860859, 7 pages, 2016. doi:10.1155/2016/2860859

2. Kim K-H, Ko D-K, Kim Y-T, Kim NH, Paul J, Zhang S-Q, Murray CB, Acharya R, DeGrado WF, Kim YH, Grigoryan G. Protein-directed self-assembly of a fullerene crystal. Nature Communications. 2016, Apr 26;7: doi:10.1038/ncomms11429.

3. Kim Y-T*, Kim K-H*, Kang ES*, Jo G, Ahn SY, Park SH, Kim SI, Mun S, Beak K, Kim B, Lee K, Yum WS, Kim YH. Synergistic Effect of Detection and Separation for Pathogen using Magnetic Clusters. Bioconjugate Chem. 2016, Jan;27(1): 59–65.

4. Kim K-H*, Hong SK*, Hwang KY and Kim EE. Structure of mouse muskelin discoidin domain and biochemical characterization of its self-association. Acta Crystallogr D Biol Crystallogr. 2014, Nov;70(Pt 11):2863-2874.

5. Kim K-H*, Lee WK*, Choi K and Kim EE. Structures of actinonin-bound peptide deformylases from Enterococcus faecalis and Streptococcus pyogenes. J Korean Soc Appl Biol Chem. 2014, Oct; 57(5), 565-571.

6. Lee WK , Son SH, Jin BS, Na JH, Kim SY, Kim KH, Kim EE, Yu YG, Lee HH. Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140. Proc. Natl. Acad. Sci. U S A. 2013, Nov 26;110(48):19360-19365.

7. Kim K-H, Ahn HJ, Lee WK, Lee C, Yu MH, Kim EE. Novel β-structure of YLR301w from Saccharomyces cerevisiae. Acta Crystallogr D Biol Crystallogr. 2012, May;68(Pt 5):531-540.

8. Kim K-H, Ha BH, Kim SJ, Hong SK, Hwang KY, Kim EE. Crystal structures of Enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis. J Mol Biol. 2011, Feb 25;406(3):403-415.

9. Kim SJ, Ha BH, Kim K-H, Hong SK, Shin KJ, Suh SW, Kim EE. Dimeric and tetrameric forms of enoyl-acyl carrier protein reductase from Bacillus cereus. Biochem Biophys Res Commun. 2010, Oct 1;400(4):517-522.

10. Hong SK, Kim K-H, Park JK, Jeong KW, Kim Y, Kim EE. New design platform for malonyl-CoA-acyl carrier protein transacylase. FEBS Lett. 2010, Mar 19;584(6):1240-1244.

11. Hong SK, Kim K-H, Kim EE. Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of MCAT from Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010, Jan 1;66(Pt 1):20-22.

12. Han KC, Kim JH, Kim K-H, Kim EE, Seo JH, Yang EG. Identification of farnesoid X receptor modulators by a fluorescence polarization-based interaction assay. Anal Biochem. 2010, Mar 15;398(2):185-190.

13. Nam KH, Kim K-H, Kim EE, Hwang KY. Crystal structure of an EfPDF complex with Met-Ala-Ser based on crystallographic packing. Biochem Biophys Res Commun. 2009, Apr 17;381(4):630-633.

14. Kim K-H, Jung EJ, Im H, Lelie DV, Kim EE. Expression, purification, and crystallization and preliminary X-ray crystallographic analysis of CnrX from Cupriavidus metallidurans CH34. J Microbiol Biotechnol. 2008, Jan;18(1):43-47.

15. Park JK, Kim K-H, Moon JH, Kim EE. Characterization of peptide deformylase2 from B. cereus. J Biochem Mol Biol. 2007, Nov 30;40(6):1050-1057.

16. Kim K-H*, Bong YJ*, Park JK, Shin KJ, Hwang KY, Kim EE. Structural basis for glutamate racemase inhibition. J Mol Biol. 2007, Sep 14;372(2):434-443.

17. Kim K-H, Park JK, Ha BH, Moon JH, Kim EE. Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007, Mar 1;63(Pt 3):246-248.



Patents

1. BIOCOMPATIBLE PROTEIN, BIOCOMPATIBLE PROTEIN GEL AND BIOCOMPATIBLE CONDUCTIVE PROTEIN GEL COMPRISING THE PROTEIN AND PREPARING METHOD THEREOF (10-2015-0016171)

2. DESING OF PEPTIDES TO DEVELOP NEW TYPE OF ANTIBODY PROBE
(10-2015-0016243)

3. 생체적합성 단백질, 이를 포함하는 생체적합성 단백질 젤과 전도성 단백질 젤 및 그의 제조방법
- 국내 특허 등록 완료, (등록번호 : 10-1551143, 출원번호 : 10-2015-0016171)

4. Biocompatible protein, biocompatible protein gel and biocompatible conductive protein gel comprising the protein and method for preparing the same
- 국제 특허 제출 완료, (출원번호 : 14/811,350), 미국

5. 코일드 코일 단백질 및 그의 용도
- 국내 특허 출원 완료, (출원번호 : 10-2016-0011506)



Research Experience

2016.02 ~ present Research professor
Sungkyunkwan University
Sungkyunkwan Advanced Institute of Nanotechnology (SAINT)

2014.05 ~ 2016.01 Postdoctoral Fellow
Sungkyunkwan University
Sungkyunkwan Advanced Institute of Nanotechnology (SAINT)

2011.03 ~ 2014.04.22 Postdoctoral Fellow
Korea Institute of Science and Technology (KIST)
Biomedical Research Institute

2005.09 ~ 2006.08 Research scientist
Korea Institute of Science and Technology (KIST)
Life Sciences Division


Honors and Awards 

2007.08.10 Scholarship for Excellence in Research, Korea Institute of Science and Technology

2012.11.22 Rising Scholarship Award, Korean Synchrotron Radiation User’s Association



Presentations

1. Ahn SY, Kim Y-T, Kim KH, Kim JH, Kim YH. Rational Design of hierarchical self-assembly of β-peptide toward electrically and mechanically enhanced hydrogel. APPA2014 Jeju Conference. May 18, 2014, Jeju, Korea.

2. Hong SK, Kim KH, Kim EE. Crystal structure of discoidin domain from mouse muskelin. 2014 KSBMB Annual Meeting. May 16, 2014, Seoul, Korea.

3. Hong SK, Kim KH, Hwang KY, Kim EE. Crystal Structure of IUS-SPRY Domain from RanBPM/10 Family. Korean Crystallographic Association Meeting. Nov 1, 2013, Seoul, Korea.

4. Hong SK, Kim KH, Hwang KY, Kim EE. Structural Analysis of SPRY/B30.2 Domain Proteins. International Conference of the Korean Society for Molecular and Cellular Biology. Oct 11, 2013, Seoul, Korea.

5. Hong SK, Kim KH, Hwang KY, Kim EE. Structure of IUS-SPRY domain from RanBPM and RanBP10. International Conference of the Korean Society for Molecular and Cellular Biology. Oct 11, 2013, Seoul, Korea.

6. Kim KH, Kim EE. Crystal Structure of the Metal-Sensor CnrX from Cupriavidus metallidurans CH34. The 24th Annual Meeting of the Korean Society for Molecular and Cellular Biology. Oct 12, 2012, Seoul, Korea.

7. Shin SC, Lee JH, Kim KH, Park JK, Keum GC, Kim EE. Structural and Thermodynamic Characterization of 2-Aminopurine Derivatives as Heat Shock Protein 90 Inhibitors. The 24th Annual Meeting of the Korean Society for Molecular and Cellular Biology. Oct 12, 2012, Seoul, Korea.

8. Kim KH, Anh HJ, Lee WK, Lee CJ, Yu MH, Kim EE. Dimeric Structure of YLR301w from Saccharomycces. The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology. Oct 6, 2011, Seoul, Korea.

9. Shin SC, Kim KH, Park JK, Keum GC, Kim EE. Binding of BIIB-021 and 17AAG to HSP90 and GRP94. The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology. Oct 6, 2011, Seoul, Korea.

10. Kim SJ, Kim KH, Suh SW, Kim EE. Dimeric and Tetrameric forms of enoyl-ACP reductase. XXII congress and General Assembly of the International Union of Crystallography. Aug 25, 2011, Madrid, Spain.

11. Shin SC, Kim KH, Park JK, Keum GC, Kim CW, Kim EE. BIIB-021 Binding to th N-terminal domain of Hsp90-structural and Thermodynamic Characterization. The 22nd Annual Meeting of the Korean Society for Molecular and Cellular Biology. Oct 8, 2010, Seoul, Korea.

12. Kim KH, Kim SJ, Hong SK, Kim EE. Structural comparison for Enoyl-ACP Reductase I(FabI) and III(FabL) from Bacillus subtilis. The 22nd Annual Meeting of the Korean Society for Molecular and Cellular Biology. Oct 8, 2010, Seoul, Korea.

13. Park JK, Kim KH, Kim EE. Molecular insights of p97 and adaptor protein fas-associated factor 1. 2010 KSBMB Annual Meeting. May 18, 2010, Seoul, Korea.

14. Kim SJ, Kim KH, Ha BH, Shin KJ, Suh SW, Kim EE. Cyrstal structures of bacillus cereus enoyl-acyl carrier protein reductase in free and complexed to nadp+ and an indole naphthyridinone. 2010 KSBMB Annual Meeting. May 17, 2010, Seoul, Korea.

15. Hong SK, Kim KH, Park JK, Kim YM, Kim EE. New Design Platform for Malonyl-CoA-Acyl Carrier Protein Transacylase. The 21th Annual Meeting of the Korean Society for Molecular and Cellular Biology. Oct 16, 2009, Seoul, Korea.

16. Kim KH, Jung EJ, Im H, Daniel L, Kim EE. Expression, purification, and crystallization and preliminary X-ray crystallographic analysis of CnrX from Cupriavidusmetallidurans CH34. Korean Crystallographic Association Meeting. May 23, 2008, Seoul, Korea.

17. Hong SK, Kim KH, Park JK, Chong YH, Kim JH, Kim EE. Structure of BsFabF/Cerulenin Complex. The 19th Annual Meeting of the Korean Society for Molecular and Cellular Biology. Oct 18, 2007, Seoul, Korea.

18. Park JK, Kim KH, Moon JH, Kim EE. Characterization of PDF2 from Bacillus cereus. 19th FAOBMB Seoul Conference. May 28, 2007, Seoul, Korea.

19. Kim KH, Park JK, Ha BH, Moon JH, Kim EE. Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis. 19th FAOBMB Seoul Conference. May 28, 2007, Seoul, Korea.

20. Kim KH, Bong YJ, Park JK, Shin KJ, Hwang KY, Kim EE. Structural Basis for Glutamate Racemase Inhibition. 19th FAOBMB Seoul Conference. May 28, 2007, Seoul, Korea.

21. Kim KH, Moon JH, Lee HK, Kim IY, Kim EE. Structural Studies of Actinonin Bound Peptide Deformylases and Implication in Drug Design. 5th International Symposium on Antimicrobial Agents and Resistance. April 28, 2005, Seoul, Korea.


Deposited Structures

- Novel fold & unknown function : 3RBY
- Enoyl-ACP reductase : 3OIC, 3OID, 3OIF, 3OIG, 3OJE, 3OJF
- Peptide deformylase : 2OS0, 2OS1, 2OS3
- Glutamate racemase : 2OHO, 2OHV, 2OHG
- Fas-associated factor 1 : 3QWZ, 3QX1
- Malonyl acyl carrier protein transacylase : 3IM8, 3IM9
- Ran binding protein 9 (RanBPM) : 4ORP, 4ORQ
- Ran binding protein 10 : 4ORT
- Muskelin : 4PQQ
- Cnr system : 4QM2(CnrX-apo), 4QM3(CnrX-Ni), 4QM4(CnrX/CnrY), 4QM5(CnrY/CnrH)