Minsuk Kwak, Ph.D.

Life Science Research Foundation Postdoctoral Fellow  

University of California, San Francisco (UCSF) & Sungkyunkwan University

1505 4th Street, Apt 502, San Francisco, CA 94158, USA

Email: sukgi333@gmail.com / Minsuk.Kwak@ucsf.edu


Education

Yale University

New haven, CT, USA

Ph.D. in Biomedical Engineering

2012.01-2017.01

M.S. in Biomedical Engineering

2012.01-2014.05

Thesis Advisor: Rong Fan, PhD (Yale University, Biomedical Engineering)

Rice University  

Houston, TX, USA

B.S. in Bioengineering  

2007.08-2011.05


Professional Experiences

Life Science Research Foundation Postdoctoral Fellow

2017.01-Present

Department of Otolaryngology, Department of Pharmaceutical Chemistry, University of California, San Francisco (UCSF), Advisor: Young-wook Jun, PhD, UCSF

 

Visiting Postdoctoral Fellow

2018.10-2020.03

Yonsei-IBS Institute, Center for Nanomedicine, Yonsei University

 

Graduate Research Assistant

2012.01-2016.10

Yale University, Department of Biomedical Engineering

Advisor: Rong Fan, PhD, Yale University

 

Research and Clinical Intern

2010.05-2010.09

University of Texas MD Anderson Cancer Center, Department of Immunology

Advisor: Chengming Ben Zhu, PhD, UT MD Anderson Cancer Center


Publication

Kwak M*, Choi JY*, Kim S, Xhangolli I, Han L, Craft JE, Fan R, Integrated single-cell analysis of circulating CXCR5+ CD4+ T cells Reveals Functional and Transcriptional Correlates to Systemic Lupus Erythematosus, in preparation (2019)

Kwak M*, Gu W*, Jeong H, Lee HJ, Lee JU, An M, Kim YH, Lee JH, Cheon J, Jun YW (* equal Contribution), Small, clickable, and monovalent magnetofluorescent nanoparticles (MFNs) enable mechanogenetic regulation of receptors in a crowded live cell microenvironment, Nano Letters (IF:12.08), ASAP, doi: 10.1021/acs.nanolett.9b00891 (2019)

Janiszewska M, Tabassum DP, Castano Z, Cristea S, Yamamoto KN, Kingston NL, Murphy KC, Shu S, Harper NW, Alcazar CGD, Aleckovic M, Ekram MB, Cohen O, Kwak M, Qin Y, Laszewski T, Luoma A, Marusyk A, Wucherpfennig KW, Wagle N, Fan R, Michor F, McAllister SS, Polyak K, Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments, Nature Cell Biology (IF:19.06), accepted and in press (2019)

Wang N, Zheng J, Chen Z, Liu Y, Dura B, Kwak M, Xavier-Ferrucia J, Lu YC, Roden C, Cheng J, Krauss D, Ding Y, Fan R, Lu J, Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms, Nature Communication (IF:12.35), 10(1): 95, doi: 10.1038/s41467-018-07981-6 (2018)

Huh SJ, Alcazar CR, Ekram MB, Trinh A, Liu LL, Beca F, Zi X, Kwak M, Bergholtz H, Su Y, Ding L, Russnes HG, Richardson AL, Babski K, Kim EMH, McDonnell III CH, Wagner J, Rowberry R, Freeman GJ, Deborah Dillon D, Sorlie T, Coussens LM, Garber JE, Bobolis K, Allred DC, Park SY, Fan R, Michor F, and Polyak K, Immune escape in breast cancer during in situ to invasive carcinoma transition, Cancer Discovery (IF:24.37), 7(10):1098-1115. doi: 10.1158/2159-8290.CD-17-0222 (2017)

Jayatilaka H, Tyle P, Chen JJ, Kwak M, Ju JA, Kim HJ, Lee JSH, Wu PH, Fan R, Gilkes DM, Wirtz D, Novel synergistic IL6/8 paracrine signaling pathway infers new strategy to inhibit tumor cell migration, Nature Communications (IF:12.35), 8, 15584 doi: 10.1038/ncomms15584 (2017).

Chen JJ, Kwak M, Fan R, Single-cell cytokine profiling to investigate cellular functional diversity in hematopoietic malignancies, Methods in Molecular Biology, 1465:243-54, doi: 10.1007/978-1-4939-4011-0_19 (2016)

Kwak M*, Han L*, Chen JJ, Fan R (* equal Contribution), Interfacing Inorganic Nanowire Arrays and Living Cells for Cellular Function Analysis, Small (IF:9.6), 11(42), 5600-10, doi:10.1002/smll.201501236 (2015)

Kleppe M*, Kwak M*, Koppikar P, Riester M, Keller M, Bastian L, Hricik T, Bhagwat N, McKenney AS, Papalexi E, Abdel-Wahab O, Rampal R, Marubayashi S, Chen JJ, Romanet V, Fridman JS, Bromberg J, Teruya-Feldstein J, Murakami M, Radimerski T, Michor F, Fan R, Levine RL (*equal contribution), JAK-STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response, Cancer Discovery (IF:24.37), 5(3): 316-313, doi: 10.1158/2159-8290 (2015),

Mao L, Shen L, Chen J, Wu Y, Kwak M, Lu Y, Xue Q, Pei J, Zhang L, Yuan G, Fan R, Ge J, Ding W, Enhanced Bioactivity of Mg-Nd-Zn-Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application, ACS Applied Material and Interfaces (IF:8.097), 7(9): 5320-5330, doi: 10.1021/am5086885 (2015)

Kwak M*, Kim DJ, Lee MR, Wu Y, Han L, Lee SK, Fan R, Nanowire Array Chips for Molecular Typing of Rare Trafficking Leukocytes with Application to Neurodegenerative Pathology, Nanoscale (IF:7.233), 6(12):6537-50, doi: 10.1039/c3nr06465d (2014)

Lee SK, Kim DJ, Lee GH, Kim GS, Kwak M, Fan R, Specific Rare Cell Capture Using Micropatterned Silicon Nanowire Platform, Biosensors and Bioelectronics (IF:8.173), 54: 181-188, doi: 10.1016/j.bios.2013.10.048 (2014)

Kwak M*, Mu L, Lu Y, Chen JJ, Brower K, Fan R, Single-cell Protein Secretomic Signatures as Potential Correlates to Tumor Cell Lineage Evolution and Cell-cell Interaction, Frontiers in Oncology (IF:4.416), 3(10), doi: 10.3389/fonc.2013.00010 (2013)

Lee SK, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R, Nanowire Substrate-based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells, Nano Letters (IF:12.08), 12(6): 2697-2704, doi: 10.1021/nl2041707 (2012)


Honors and Awards

1.     Burroughs Wellcome Fund 2018 Collaborative Research Travel Award, 2018-2019 ($10,000)

2.     Life Science Research Foundation (LSRF) Postdoctoral Research Fellowship, The Shurl and Kay Curci Foundation, 2018-2021: $52,000/year salary and benefit, $10,000/year research allowance for 3 years

3.     AACR Lymphoma Research Postdoctoral Fellowship, American Association of Cancer Research, 2018-2020: $55,000/year salary and benefit for 2 years (declined)

4.     Individual Basic Science & Engineering Research Program, National Research Foundation of Korea, 2017-2018: annual research support of $50,000 per project, awarded 2 years support

5.     Edward L. Barlow Fellowship, Yale University, 2015-2016: Selected from Yale Graduate School of Arts and Sciences, Department of Biomedical Engineering, Graduate School Tuition and Support.

6.     Conference Travel Fellowship, 2015 (Yale University): Financial assistance is awarded on a competitive basis to students who are presenting their original work at academic conferences ($1000).

7.     Best Poster Award Nominee, 2014 Spring Material Research Society Spring Meeting and Exhibition (Material Research Society), 2014: Selected as one of the most outstanding poster presentations

8.     Institution Nomination for Howard Hughes Medical Institute (HHMI) International Student Research Fellowship (Yale University, HHMI), 2012: One of 10 finalists representing Yale University

9.     Allen International Fellowship (Rice University), 2007-2011: Merit-based scholarships for outstanding international students. Full university tuition and fee, renewable for 4 years ($124,000)

10.  STEP-UP Clinical & Research Internship (UT MD Anderson Cancer Center, UT Houston Health Science Center), 2010: 10-week long research internship and observational clinical rotation, Stipend ($4,250)



Selected Conference Presentations

1.     Kwak M*, Catherine B. Carbone, Ronald D. Vale, and Young-wook Jun, “Dissecting T cell signaling with single-cell nanotechnology tools, 2018 Life Science Research Foundation Annual Meeting, Houston, TX (2018)

2.     Kwak M*, Choi JY, Han L, Xhangolli I, Craft JE, and Fan R, “Single-cell cytokine and transcriptome profiling of circulating Tfh cells in patients with systemic lupus erythematosus”, The 3rd Single Cell Genomics Meeting, Utrecht, The Netherlands (2015). [Poster Presentation].

3.     Choi JY, Kwak M, Seth A, Weinstein J, Herman E, Fan R, and Craft JE, “Clinical Assessment and Therapeutic Blackade of T-B Cell Collaboration in Lupus”, 2015 Department of Immunobiology Retreat, Yale School of Medicine,

4.     Kwak M*, Choi JY, Han L, Xhangolli I, Craft JE, Fan R, “Single-cell Cytokine Profiling of Circulating TFH Cells Reveals Pathogenically Transformed Cytokine Programs in Systemic Lupus Erythematosus”, 6th Annual Human and Translational Immunology (HTI) Retreat, April 7. New Haven, CT (2015). [Poster Presentation]

5.     Kwak M*, Kim DJ, Han L, Lee MR, Wu Y, Lee SK, Fan R, “Nanowire Array Chips for Rare Cell Analysis with Application to Neurodegenerative Pathology”, 2014 MRS Spring Meeting and Exhibit, April 21-25, 2014, San Francisco, CA (2014). [Poster Presentation, Symposium Assistant Organizer]

6.     Mao L, Kwak K, Shen L, Fan R, Yuan G, “Biodegradable Magnesium Vascular Stent with Low Inflammatory Response and Reduced In-Stent Restenosis”, 2013 BMES Annual Meeting, September 25-28, Seattle, WA (2013). [Poster Presentation]

7.     Kwak K*, Kleppe M, Chen JJ, Lu Y, Michor F, Levine RL, Fan R, “Dissecting Cytokine Signaling in Myeloproliferative Neoplasm at the Level of Single-Cells”, 4th Annual National Cancer Institute Physical Science-Oncology Centers (PS-OCs) Network Investigator’s Meeting, April 17-19, Scottsdale, AZ (2013). [Poster Presentation]

8.     Kwak K*, Lee SK, Lu Y, Wu Y, Han L, Gonzales A, Li J, Fan R, “Nanowire Arrays for Rare Cell Analysis”, Gordon Research Conference on Nanostructure Fabrication, July 15-20, Biddeford, ME (2012). [Poster Presentation]