1. Design of Supramolecular Protein Assemblies for Nano and Biomedical Applications: : design of supramolecular protein assemblies for nano and biomedical applications - Coiled coil - Helical barrel - Channel protein - 2D/3D templated protein assemblies - Bio-inspired cathod material in fuel cell - Biomimetic solar cell ![]() My second project in this field was geared towards designing pepides that associate with fullerene. ![]() ![]() The simulation-guided design principle enables us to engineer a peptide assembly formed only in the presence of a pristine graphene surface. In particular, a rationally designed peptide sequence resulting in the formation of peptide assembly on the surface of a pristine graphene was supported from atomistic simulations in the viewpoint of both thermodynamic stability and energetics. It is shown that for a rationally designed peptide sequence, the structure of peptide self-assembly is thermodynamically stable and is energetically optimized such that both peptide-peptide interactions and peptide-graphene interactions are maximized. 2. Fundamental studies of Protein Folding for diseases such as Diabetes and Brain diseases : Elucidating the structure of pro-human Islet amyloid peptide (pro-hIAPP) in human type diabetes. - Anaylsis the structural and dynamic properties using X-ray crystallography and femto-second FTIR ![]() - Predict possible structure by homological sequence-dependent modeling and simulate the dynamics of protein in aqueous solution or cytoplasm-like environment ![]() 3. Functional Protein Material Design for Brain imaging, Stem Cell, Angiogensis, Antibacterial and Cosmetics. ![]() Our biomaterial design lab focuses on design and structural characterization of protein-based biomaterials that can be toward to make cellular and molecular therapies effective and practical approaches eventually to treat disease. New biomaterials are now designed rationally or computationally with controlled assembly structure and dynamic functionality to integrate with biological complexity and perform tailored, high-level functions in the body. These biomaterials designs are used to study the mechanisms by which chemical or mechanical signals are sensed by cells, alter cell function and further brain function in vivo. 4. Surface Chemistry for biosensor - Super-hydrophobic - Protein assemblies on 2D-materials - Conducting bio-surfaces - Simulation of protein behavior on solid surfaces ex) Single-Molecule Protein Arrays on Sub-10-nm Lithographic Surfaces ![]() Templating assembly of biomolecules can create complex nanostructured devices with precisely tailored chemical or biological responses, with applications in, for example, biomedical or environmental sensors. In this research project, we have focused on developing methods for creating complex molecular top-down templating of assembled structures of proteins or DNAs that is relevant to a range of devices. Themain goal is therefore to guide the self-assembly process using engineered ![]()
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